Dendrimers for siRNA Delivery
نویسندگان
چکیده
منابع مشابه
Dendrimers for siRNA Delivery
Since the discovery of the "starburst polymer", later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively...
متن کاملPAMAM dendrimers for efficient siRNA delivery and potent gene silencing.
Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.
متن کاملAcetylation of PAMAM dendrimers for cellular delivery of siRNA
BACKGROUND The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process. In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM)...
متن کاملPAMAM dendrimers for siRNA delivery: computational and experimental insights.
Short double-stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down-regulate the expression of the targeted gene in a process known as RNA interference (RNAi). However, the success of gene silencing applications based on the use of synthetic siRNA critically depends on efficient intracellular delivery. Polycationic branched macromolecules such as poly(...
متن کاملDendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review
RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA) are used to specifically downregulate the expression of the targeted gene, known as the term "gene silencing." One key point for successful gene silencing is to employ a safe and efficient...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2013
ISSN: 1424-8247
DOI: 10.3390/ph6020161